PittsburghV1, Main, Exploration, bibRecord, 001A43

Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation

Identifieur interne : 001A43 ( Main/Exploration ); précédent : 001A42; suivant : 001A44

Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation

Auteurs : Rupal J. Shah [États-Unis] ; Nancy Wickersham [États-Unis] ; David J. Lederer [États-Unis] ; Scott M. Palmer [États-Unis] ; Edward Cantu [États-Unis] ; Joshua M. Diamond [États-Unis] ; Steven M. Kawut [États-Unis] ; Vibha N. Lama [États-Unis] ; Sangeeta Bhorade [États-Unis] ; Maria Crespo [États-Unis] ; Ejigayehu Demissie [États-Unis] ; Joshua Sonett [États-Unis] ; Keith Wille [États-Unis] ; Jonathan Orens [États-Unis] ; Ann Weinacker [États-Unis] ; Pali Shah [États-Unis] ; Selim Arcasoy [États-Unis] ; David S. Wilkes [États-Unis] ; Jason D. Christie [États-Unis] ; Lorraine B. Ware [États-Unis]

Source :

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6135 ] ; 2014.

RBID : PMC:3946770

Abstract

Inherent recipient factors, including pre-transplant diagnosis, obesity, and elevated pulmonary pressures are established PGD risks. We evaluated the relationship between pre-operative lung injury biomarkers and PGD to gain further mechanistic insight in recipients. We performed a prospective cohort study of recipients in the lung transplant outcomes group enrolled between 2002 and 2010. Our primary outcome was grade 3 PGD on day 2 or 3. We measured pre-operative plasma levels of 5 biomarkers (CC-16, sRAGE, ICAM-1, IL-8, and Protein C) that were previously associated with PGD when measured at the post-operative timepoint. We used multivariable logistic regression to adjust for potential confounders. Of 714 subjects, 130 (18%) developed PGD. Median CC-16 levels were elevated in subjects with PGD (10.1 vs. 6.0, p<0.001). CC-16 was associated with PGD in non-IPF subjects (OR for highest quartile of CC-16: 2.87, 95% CI: 1.37, 6.00, p=0.005) but not in subjects with IPF (OR 1.38, 95% CI: 0.43, 4.45, p=0.59). After adjustment, pre-operative CC-16 levels remained associated with PGD (OR: 3.03, 95% CI: 1.26, 7.30, p=0.013) in non-IPF subjects. Our study suggests the importance of pre-existing airway epithelial injury in PGD. Markers of airway epithelial injury may be helpful in pre-transplant risk stratification in specific recipients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946770

DOI: 10.1111/ajt.12541
PubMed: 24400993
PubMed Central: 3946770

Affiliations:

Le document en format XML

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<author><name sortKey="Shah, Rupal J" sort="Shah, Rupal J" uniqKey="Shah R" first="Rupal J." last="Shah">Rupal J. Shah</name>
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<author><name sortKey="Lama, Vibha N" sort="Lama, Vibha N" uniqKey="Lama V" first="Vibha N." last="Lama">Vibha N. Lama</name>
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<author><name sortKey="Bhorade, Sangeeta" sort="Bhorade, Sangeeta" uniqKey="Bhorade S" first="Sangeeta" last="Bhorade">Sangeeta Bhorade</name>
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<author><name sortKey="Crespo, Maria" sort="Crespo, Maria" uniqKey="Crespo M" first="Maria" last="Crespo">Maria Crespo</name>
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<author><name sortKey="Demissie, Ejigayehu" sort="Demissie, Ejigayehu" uniqKey="Demissie E" first="Ejigayehu" last="Demissie">Ejigayehu Demissie</name>
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<author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name>
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</placeName>
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<author><name sortKey="Wille, Keith" sort="Wille, Keith" uniqKey="Wille K" first="Keith" last="Wille">Keith Wille</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
<wicri:cityArea>Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea>
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</author>
<author><name sortKey="Orens, Jonathan" sort="Orens, Jonathan" uniqKey="Orens J" first="Jonathan" last="Orens">Jonathan Orens</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Pulmonary and Critical Care, Stanford University, Palo Alto, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pulmonary and Critical Care, Stanford University, Palo Alto</wicri:cityArea>
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<author><name sortKey="Weinacker, Ann" sort="Weinacker, Ann" uniqKey="Weinacker A" first="Ann" last="Weinacker">Ann Weinacker</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Surgery, Johns Hopkins University Hospital, Baltimore, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Surgery, Johns Hopkins University Hospital, Baltimore</wicri:cityArea>
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<author><name sortKey="Shah, Pali" sort="Shah, Pali" uniqKey="Shah P" first="Pali" last="Shah">Pali Shah</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Pulmonary and Critical Care, Stanford University, Palo Alto, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pulmonary and Critical Care, Stanford University, Palo Alto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name>
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<region type="state">Pennsylvanie</region>
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<author><name sortKey="Wilkes, David S" sort="Wilkes, David S" uniqKey="Wilkes D" first="David S." last="Wilkes">David S. Wilkes</name>
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<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Indiana University School of Medicine, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Christie, Jason D" sort="Christie, Jason D" uniqKey="Christie J" first="Jason D." last="Christie">Jason D. Christie</name>
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<affiliation wicri:level="3"><nlm:aff id="A6">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Ware, Lorraine B" sort="Ware, Lorraine B" uniqKey="Ware L" first="Lorraine B." last="Ware">Lorraine B. Ware</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, Tennessee</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation</title>
<author><name sortKey="Shah, Rupal J" sort="Shah, Rupal J" uniqKey="Shah R" first="Rupal J." last="Shah">Rupal J. Shah</name>
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<author><name sortKey="Wickersham, Nancy" sort="Wickersham, Nancy" uniqKey="Wickersham N" first="Nancy" last="Wickersham">Nancy Wickersham</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
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<author><name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Palmer, Scott M" sort="Palmer, Scott M" uniqKey="Palmer S" first="Scott M." last="Palmer">Scott M. Palmer</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University, Raleigh-Durham</wicri:cityArea>
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<author><name sortKey="Cantu, Edward" sort="Cantu, Edward" uniqKey="Cantu E" first="Edward" last="Cantu">Edward Cantu</name>
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<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
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</affiliation>
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<author><name sortKey="Diamond, Joshua M" sort="Diamond, Joshua M" uniqKey="Diamond J" first="Joshua M." last="Diamond">Joshua M. Diamond</name>
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<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
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<author><name sortKey="Kawut, Steven M" sort="Kawut, Steven M" uniqKey="Kawut S" first="Steven M." last="Kawut">Steven M. Kawut</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Lama, Vibha N" sort="Lama, Vibha N" uniqKey="Lama V" first="Vibha N." last="Lama">Vibha N. Lama</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Division of Pulmonary, Allergy, and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Michigan</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, University of Michigan, Ann Arbor</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bhorade, Sangeeta" sort="Bhorade, Sangeeta" uniqKey="Bhorade S" first="Sangeeta" last="Bhorade">Sangeeta Bhorade</name>
<affiliation wicri:level="2"><nlm:aff id="A9">Division of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Illinois</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Division of Pulmonary and Critical Care Medicine, University of Chicago, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Crespo, Maria" sort="Crespo, Maria" uniqKey="Crespo M" first="Maria" last="Crespo">Maria Crespo</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh, Pittsburgh, Pennsylvania</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care, University of Pittsburgh, Pittsburgh</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Demissie, Ejigayehu" sort="Demissie, Ejigayehu" uniqKey="Demissie E" first="Ejigayehu" last="Demissie">Ejigayehu Demissie</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
</placeName>
<wicri:cityArea>Department of Surgery, Columbia University College of Physicians and Surgeons, New York</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Wille, Keith" sort="Wille, Keith" uniqKey="Wille K" first="Keith" last="Wille">Keith Wille</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Alabama</region>
</placeName>
<wicri:cityArea>Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Birmingham</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Orens, Jonathan" sort="Orens, Jonathan" uniqKey="Orens J" first="Jonathan" last="Orens">Jonathan Orens</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Pulmonary and Critical Care, Stanford University, Palo Alto, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pulmonary and Critical Care, Stanford University, Palo Alto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Weinacker, Ann" sort="Weinacker, Ann" uniqKey="Weinacker A" first="Ann" last="Weinacker">Ann Weinacker</name>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Surgery, Johns Hopkins University Hospital, Baltimore, Maryland</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Department of Surgery, Johns Hopkins University Hospital, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Shah, Pali" sort="Shah, Pali" uniqKey="Shah P" first="Pali" last="Shah">Pali Shah</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Pulmonary and Critical Care, Stanford University, Palo Alto, CA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Department of Pulmonary and Critical Care, Stanford University, Palo Alto</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Division of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Division of Cardiovascular Surgery, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Wilkes, David S" sort="Wilkes, David S" uniqKey="Wilkes D" first="David S." last="Wilkes">David S. Wilkes</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Division of Pulmonary, Allergy, and Critical Care Medicine, Indiana University School of Medicine, Indianapolis, IN</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Indiana</region>
</placeName>
<wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Indiana University School of Medicine, Indianapolis</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Christie, Jason D" sort="Christie, Jason D" uniqKey="Christie J" first="Jason D." last="Christie">Jason D. Christie</name>
<affiliation wicri:level="3"><nlm:aff id="A1">Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A7">Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia</nlm:aff>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
<wicri:orgArea>Penn Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Ware, Lorraine B" sort="Ware, Lorraine B" uniqKey="Ware L" first="Lorraine B." last="Ware">Lorraine B. Ware</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville, Tennessee</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Division of Allergy, Pulmonary, and Critical Care Medicine Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Tennessee</region>
</placeName>
<wicri:cityArea>Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title>
<idno type="ISSN">1600-6135</idno>
<idno type="eISSN">1600-6143</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Inherent recipient factors, including pre-transplant diagnosis, obesity, and elevated pulmonary pressures are established PGD risks. We evaluated the relationship between pre-operative lung injury biomarkers and PGD to gain further mechanistic insight in recipients. We performed a prospective cohort study of recipients in the lung transplant outcomes group enrolled between 2002 and 2010. Our primary outcome was grade 3 PGD on day 2 or 3. We measured pre-operative plasma levels of 5 biomarkers (CC-16, sRAGE, ICAM-1, IL-8, and Protein C) that were previously associated with PGD when measured at the post-operative timepoint. We used multivariable logistic regression to adjust for potential confounders. Of 714 subjects, 130 (18%) developed PGD. Median CC-16 levels were elevated in subjects with PGD (10.1 vs. 6.0, p<0.001). CC-16 was associated with PGD in non-IPF subjects (OR for highest quartile of CC-16: 2.87, 95% CI: 1.37, 6.00, p=0.005) but not in subjects with IPF (OR 1.38, 95% CI: 0.43, 4.45, p=0.59). After adjustment, pre-operative CC-16 levels remained associated with PGD (OR: 3.03, 95% CI: 1.26, 7.30, p=0.013) in non-IPF subjects. Our study suggests the importance of pre-existing airway epithelial injury in PGD. Markers of airway epithelial injury may be helpful in pre-transplant risk stratification in specific recipients.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Alabama</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Illinois</li>
<li>Indiana</li>
<li>Maryland</li>
<li>Michigan</li>
<li>Pennsylvanie</li>
<li>Tennessee</li>
<li>État de New York</li>
</region>
<settlement><li>Philadelphie</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Shah, Rupal J" sort="Shah, Rupal J" uniqKey="Shah R" first="Rupal J." last="Shah">Rupal J. Shah</name>
</region>
<name sortKey="Arcasoy, Selim" sort="Arcasoy, Selim" uniqKey="Arcasoy S" first="Selim" last="Arcasoy">Selim Arcasoy</name>
<name sortKey="Bhorade, Sangeeta" sort="Bhorade, Sangeeta" uniqKey="Bhorade S" first="Sangeeta" last="Bhorade">Sangeeta Bhorade</name>
<name sortKey="Cantu, Edward" sort="Cantu, Edward" uniqKey="Cantu E" first="Edward" last="Cantu">Edward Cantu</name>
<name sortKey="Christie, Jason D" sort="Christie, Jason D" uniqKey="Christie J" first="Jason D." last="Christie">Jason D. Christie</name>
<name sortKey="Christie, Jason D" sort="Christie, Jason D" uniqKey="Christie J" first="Jason D." last="Christie">Jason D. Christie</name>
<name sortKey="Christie, Jason D" sort="Christie, Jason D" uniqKey="Christie J" first="Jason D." last="Christie">Jason D. Christie</name>
<name sortKey="Crespo, Maria" sort="Crespo, Maria" uniqKey="Crespo M" first="Maria" last="Crespo">Maria Crespo</name>
<name sortKey="Demissie, Ejigayehu" sort="Demissie, Ejigayehu" uniqKey="Demissie E" first="Ejigayehu" last="Demissie">Ejigayehu Demissie</name>
<name sortKey="Demissie, Ejigayehu" sort="Demissie, Ejigayehu" uniqKey="Demissie E" first="Ejigayehu" last="Demissie">Ejigayehu Demissie</name>
<name sortKey="Diamond, Joshua M" sort="Diamond, Joshua M" uniqKey="Diamond J" first="Joshua M." last="Diamond">Joshua M. Diamond</name>
<name sortKey="Kawut, Steven M" sort="Kawut, Steven M" uniqKey="Kawut S" first="Steven M." last="Kawut">Steven M. Kawut</name>
<name sortKey="Kawut, Steven M" sort="Kawut, Steven M" uniqKey="Kawut S" first="Steven M." last="Kawut">Steven M. Kawut</name>
<name sortKey="Kawut, Steven M" sort="Kawut, Steven M" uniqKey="Kawut S" first="Steven M." last="Kawut">Steven M. Kawut</name>
<name sortKey="Lama, Vibha N" sort="Lama, Vibha N" uniqKey="Lama V" first="Vibha N." last="Lama">Vibha N. Lama</name>
<name sortKey="Lederer, David J" sort="Lederer, David J" uniqKey="Lederer D" first="David J." last="Lederer">David J. Lederer</name>
<name sortKey="Orens, Jonathan" sort="Orens, Jonathan" uniqKey="Orens J" first="Jonathan" last="Orens">Jonathan Orens</name>
<name sortKey="Palmer, Scott M" sort="Palmer, Scott M" uniqKey="Palmer S" first="Scott M." last="Palmer">Scott M. Palmer</name>
<name sortKey="Shah, Pali" sort="Shah, Pali" uniqKey="Shah P" first="Pali" last="Shah">Pali Shah</name>
<name sortKey="Sonett, Joshua" sort="Sonett, Joshua" uniqKey="Sonett J" first="Joshua" last="Sonett">Joshua Sonett</name>
<name sortKey="Ware, Lorraine B" sort="Ware, Lorraine B" uniqKey="Ware L" first="Lorraine B." last="Ware">Lorraine B. Ware</name>
<name sortKey="Ware, Lorraine B" sort="Ware, Lorraine B" uniqKey="Ware L" first="Lorraine B." last="Ware">Lorraine B. Ware</name>
<name sortKey="Weinacker, Ann" sort="Weinacker, Ann" uniqKey="Weinacker A" first="Ann" last="Weinacker">Ann Weinacker</name>
<name sortKey="Wickersham, Nancy" sort="Wickersham, Nancy" uniqKey="Wickersham N" first="Nancy" last="Wickersham">Nancy Wickersham</name>
<name sortKey="Wilkes, David S" sort="Wilkes, David S" uniqKey="Wilkes D" first="David S." last="Wilkes">David S. Wilkes</name>
<name sortKey="Wille, Keith" sort="Wille, Keith" uniqKey="Wille K" first="Keith" last="Wille">Keith Wille</name>
</country>
</tree>
</affiliations>
</record>

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Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation

Pre-operative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation

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